Ta1_P04

Bomb pulse dating of human calculi

Wang ^1,2,3, Ding P^1,2,3, Shen C^1,2, Zhu S^2,4

¹State Key Laboratory of Isotope Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, , Guangzhou, China, ²CAS Center for Excellence in Deep Earth Science, Guangzhou Institute of Geochemistry, Chinese Academy of  Sciences, Guangzho, China, ³Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou), Guangzhou, China, ⁴State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China

The onset ages of various human calculus diseases are usually later than the emergence ages of calculi in the body because the patients seek medical attention after the symptoms and complications are perceptible. Knowing the emergence ages of calculi will help doctors figure out the causes and benefit public health. In this study, we collected three kinds of calculi, including sialoliths (S), gallstone (GS), and bladder stones (BS) from 8 donors in Guizhou, Southwest China. Five of these samples are big and have multiple layers. We separated them into the inner core and outer crust parts and studied their ¹⁴C ages and ¹³C signatures. The results show the bomb pulse dating ages of BS and GS (c. 0 - 6 yrs) are much younger than those of sialoliths (c. 9 - 44 yrs). The difference between the ages of the outer crusts and inner cores indicates the growth period of calculi, ranging from 0.4 to 6.9 yrs. The growth rates of GS and BS are between 2.8 to 4.1 mm/yr. The δ¹³C values of sialoliths, GS, and BS range from -23.9 to -21.5 ‰, -22.6 to -22.2 ‰, and -20.5 to -19.5 ‰, respectively. Distinguish ages and stable isotope distribution patterns likely exist among different kinds of calculi, but further studies are needed to give a statistical conclusion.