Ta1_P03

Absorption and Distribution of Ultra-Trace Exogenous ¹⁴C Urea in Rats

Wang L, Tang J^1,2, Zhang G¹, Shi S¹, Chen D¹, Qi L¹, Yang P³, Zhang X³, Xia C³, Shen H^1,2

¹Guangxi Normal University, Guilin, China, ²Guangxi key laboratory of nuclear physics and nuclear technology, Guilin, China, ³Guilin Medical University, Guilin, China

A study on absorption and distribution of radiocarbon labeled urea in rats was carried out at the ultra-trace level with AMS. The drug concentrations in plasma and tissues of rats after an oral administration of an ultra-trace dose of [¹⁴C]urea were measured. The drug concentration vs time curves in plasma and tissues were obtained. The results show that the drug distribution of ultra-trace dose is different from that of conventional-dose, and the [¹⁴C]urea is excreted mainly through urine and respiratory. This study provides information on the pharmacokinetics and tissue distribution of exogenous urea in rats at the ultra-trace level and verifies the feasibility of using AMS for ultra-trace dose drug research beyond the traditional measurement range.

Keywords: AMS, ultra-trace dose, [¹⁴C]urea, pharmacokinetics, distribution